血管紧张素转换酶基因多态性与原发性高血压的关系

目的：探讨中国人血管紧张素转换酶（ＡＣＥ）基因的插入／缺失（Ｉ／Ｄ）多态性与原发性高血压（ＥＨ）发病的相关性。方法按ＷＨＯ标准确诊的ＥＨ患者６８例,正常对照组６２例。用多聚酶链式反应（ＰＣＲ）和琼脂糖电泳技术,检测两组个体ＡＣＥ基因的Ｉ／Ｄ多态性。结果高血压组与正常对照组检测出３例基因Ⅱ、ⅠＤ和ＤＤ,频率分布分别为０．４８、０．３７、０．１５和０．３９、０．４８、０．１３,Ｉ、Ｄ等位基因频率分别为

Relationship between polymorphism of Angiotensin converting enzyme gene and essential hypertension

In order to explore the intrinsic relationship between polymorphism of ACE gene and occurrence of essential hypertension in Chinese people.Methods We studied total of 130 cases, 68 cases were diagnosed as essential hypertension according to the diagnostic standard of WHO, 62 cases were normal control. Polymerase Chain Reaction(PCR) and DNA electrophoresis techniques were applied to study ACE gene polymorphism.Results Statistic analysis of experimental results indicated that occurring frequency of ID gene was not different in the group of patients with essential hypertension from the group of normal control.Conclusions From this study we concluded that polymorphism ACE gene I/D is not related to the occurrence of essential hypertension in native Chinese people and the occurring frequency of alleles in native Chinese people is different from it in the Europeans.