| 丹参素及其衍生物的合成 |
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| 引用本文： | 张彦文,冯淑华. 丹参素及其衍生物的合成[J]. 天津医科大学学报, 2005, 11(4): 522-524 |
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| 作者姓名： | 张彦文 冯淑华 |
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| 作者单位： | 1. 天津医科大学药学院,天津,300070
2. 北京联合大学生物医药系 |
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| 基金项目： | 天津市教委基金资助（编号：20010701） |
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| 摘 要： | 目的：探讨丹参素的合成方法，并以苯基乳酸为先导化合物，通过设计、合成衍生物，对其进行结构修饰。方法：使用硼氢化钾代替锌汞齐还原羰基，通过乙酰化反应对丹参素及其衍生物进行结构修饰。结果：使用硼氢化钾将羰基还原成羟基，合成了丹参素及其衍生物的乙酰化产物，经^1H—NMR证实其结构。结论：使用硼氢化钾还原羰基，产物单一，条件温和，易于控制。
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| 关 键 词： | 丹参素 合成 还原反应 硼氢化钾 |
| 文章编号： | 1006-8147（2005）04-0522-03 |
| 修稿时间： | 2005-05-27 |
Synthesis of danshensu and derivatives |
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| ZHANG Yan-wen,FENG Shu-hua. Synthesis of danshensu and derivatives[J]. Journal of Tianjin Medical University, 2005, 11(4): 522-524 |
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| Authors: | ZHANG Yan-wen FENG Shu-hua |
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| Affiliation: | 1.Pharmacy College of Tianjing Medical University,Tianjin 300070, China ; 2.Biochemical Engineering College of Beijing Union University |
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| Abstract: | Objective: To study the method of synthesising danshensu and derivatives of phenyllactic acid as the lead compound was designed and synthesized;modify on its structure. Methods: Carbonyl group was reducted with potassium borohydride in stead of zinc amalgam; the danshensu and its derivatives were acetylated. Results: Carbonyl group was reducted with potassium borohydride to hydroxyl group aeetylated danshensu and its derivatives were synthesized ; the structures of danshensu and its derivatives were confirmed by 1H-NMR. Conclusion: The condition of reduction with potassium borohydrid is mildness and in control. |
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| Keywords: | Danshengsu Synthesising Reduction reaction Potassium borohydride |
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