2型糖尿病合并腰椎骨质疏松的临床相关因素分析

目的分析2型糖尿病骨质疏松患者腰椎骨密度（BMD）与年龄、性别、体质量、病程、空腹血糖等因素的相关性。方法收集临床资料完整的2型糖尿病合并骨质疏松患者40例为A组，使用倾向得分匹配法（PSM）确定年龄性别匹配的同期健康体检者40例为B组，两组病例均测定腰椎（L1~L4）及左侧股骨BMD，并记录性别、年龄、病程、体质量指数、空腹血糖及血钙、血磷、尿钙、尿磷等临床指标进行比较。结果A组L1~4腰椎BMD明显低于B组（P<0.05）；2型糖尿病骨质疏松患者腰椎BMD与性别相关，并与病程呈负相关，而与体质量指数（BMI）、空腹血糖、尿钙、尿磷呈正相关，但与年龄、血钙、血磷无明显相关关系。结论2型糖尿病患者骨密度降低与性别、BMI、病程延长、血糖控制不佳等因素有关。

Analysis of clinical factors correlating with osteoporosis in patients with type 2 diabetes mellitus

Objective To analyze the clinical factors that contribute to lowered bone mineral density (BMD) of the lumbarvertebrae in type 2 diabetic patients. Methods Forty type 2 diabetic patients with osteoporosis and 40 age- andgender-matched healthy individuals, selected using propensity score method, were examined for BMD of the L1 to L4vertebrae and the left femur. Age, gender, course of the disease, body mass index (BMI), fasting blood glucose, serum calcium,serum phosphate, urinary calcium, and urinary phosphate were compared between the two groups. Results BMD of the L1 toL4 vertebras was significantly lower in the diabetic group than in the healthy individuals (P<0.05). In the diabetic patients,BMD showed an obvious difference between male and female patients and was negatively correlated with the course of thedisease but positively with BMI, fasting blood glucose, urinary calcium and urinary phosphate; BMD was not correlated withage, serum calcium or serum phosphate in these patients. Conclusion Osteoporosis in type 2 diabetic patients is closely relatedwith gender, BMI, course of the disease and poorly controlled glucose level.