| Association Between IL-13 Gene Polymorphism and Asthma in Han Nationality in Hubei Chinese Population |
| |
| 作者姓名： | 习东 潘世秀 崔天盆 吴健民 |
| |
| 作者单位： | [1]DepartmentofInfectionImmunology,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China [2]DepartmentofLaboratory,UnionHospital,TongjiHospital,HuazhongUniversityofScienceandTechnology,Wuhan430022,China |
| |
| 摘 要： | In order to investigate whether Arg110Gln polymorphism in the coding region of the IL13 gene is associated with asthma and total plasma IgE level in Han nationality in Hubei Chinese population, the allele frequency of 4257 (g/a) site and Arg110Gln genotype of IL-13 was detected by using restriction fragment length polymorphism in Han nationality in Hubei Chinese population including 43 asthmatic children, 45 asthmatic adults, 31 control children and 46 control adults. Total plasma IgE was measured by Chemil.uminescence assay. The results showed that the frequency of allele A at 4257 bp of IL-13 in children and adults was 0.39 and 0.32, respectively. The GlnGln form of Arg110Gln polymorphism of IL-13 gene was associated with susceptibility of asthma and elevated total plasma IgE in children (P =0. 030 and 0. 0009, respectively), but not with them in adults (P=0. 219 and 0. 174, respectively). Our results suggest that the Arg110Gln polymorphism of IL-13 gene is associated with susceptibility of asthma and elevated total plasma IgE in Chinese children of Han nationality in Hubei, but not with them in adults.
|
| 关 键 词： | IL-13基因 基因多态性 哮喘 汉族 湖北 中国 等位基因 |
| 收稿时间： | 28 April 2004 |
Association between IL-13 gene polymorphism and asthma in Han nationality in Hubei Chinese population |
| |
| Xi?Dong,Pan?Shixiu,Cui?Tianpen,Wu?Jianmin.Association Between IL-13 Gene Polymorphism and Asthma in Han Nationality in Hubei Chinese Population[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(3):219-222. |
| |
| Authors: | Xi Dong Pan Shixiu Cui Tianpen Wu Jianmin |
| |
| Institution: | 1. Department of Infection Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
2. Department of Laboratory,Union Hospital,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430022,China |
| |
| Abstract: | Summary: In order to investigate whether Arg110Gln polymorphism in the coding region of the IL-13 gene is associated with asthma and total plasma IgE level in Han nationality in Hubei Chinese population, the allele frequency of 4257(g/a) site and Arg110Gln genotype of IL-13 was detected by using restriction fragment length polymorphism in Han nationality in Hubei Chinese population including 43 asthmatic children, 45 asthmatic adults, 31 control children and 46 control adults. Total plasma IgE was measured by Chemiluminescence assay. The results showed that the frequency of allele A at 4257 bp of IL-13 in children and adults was 0.39 and 0.32, respectively. The GlnGln form of Arg110Gln polymorphism of IL-13 gene was associated with susceptibility of asthma and elevated total plasma IgE in children (P =0.030 and 0.0009, respectively), but not with them in adults (P=0.219 and 0.174, respectively). Our results suggest that the Arg110Gln polymorphism of IL-13 gene is associated with susceptibility of asthma and elevated total plasma IgE in Chinese children of Han nationality in Hubei, but not with them in adults. |
| |
| Keywords: | asthma immunoglobulin E interleukin-13 Arg110Gln polymorphism |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ |
|
