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| 氟化物与ＤＮＡ结合作用的研究 | |
| 引用本文： | 王德泉,孔淑琴,狄海涛.氟化物与ＤＮＡ结合作用的研究[J].中国地方病防治杂志,2001,16(1):9-11. |
| 作者姓名： | 王德泉 孔淑琴 狄海涛 |
| 作者单位： | 1. 山尔省济宁市卫生防疫站,济宁,272000 2. 济宁市中区卫生防疫站 3. 中国济宁海关卫生检疫局 |
| 摘 要： | 本文应用紫外吸收光谱法、ＤＮＡ融点（Ｔm)测定法及高压液相ＬＣ－ＶＰ离子谱色分析法分别对氟化物与ＤＮＡ的结合作用进行了检测，从不同角度均证实氟化钠（ＮaF)与ＤＮＡ不能发生稳定结合，提示氟化物直接作用ＤＮＡ而造成遗传性损伤的可能性较小，但不能否认对ＤＮＡ聚合酶抑制作用而造成的损伤。 |
| 关 键 词： | 氟化物 DNA 结合作用 遗传毒理学 |
The study of the effection of the combination of the fluoride and DNA |
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| Wang Dequan,Kong Shuqin,Di Haitao.The study of the effection of the combination of the fluoride and DNA[J].Chinese Journal of Control of Endemic Disenaces,2001,16(1):9-11. | |
| Authors: | Wang Dequan Kong Shuqin Di Haitao |
| Abstract: | The effects of the combination of fluoride and DNA were dectected by ultraviolet Absorbent spectral Assay, DNA Tm Assay and High Liquid LC - VP Ion Chomatography respectively. It was confirmed that fluoride can not combine with DNA stablely. The results showed that there was less pussibility that fluoide call take effect on DNA directly and cause genetic damage. But it was not ignored that the combinatin can damage the inhibition of the DNA polymerase. |
| Keywords: | Fluoride DNA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |