Recent discoveries in the genetics of melanoma and their therapeutic implications |
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Authors: | Amélie Marquette Martine Bagot Armand Bensussan Nicolas Dumaz |
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Affiliation: | (1) Faculté de Médecine de Créteil, Department of Immunology, Dermatology, and Oncology, INSERM Unit 841, IMRB, Equipe 02, 8 rue du Général Sarrail, 94010 Créteil, France |
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Abstract: | The incidence of cutaneous malignant melanoma, tumors arising from melanocytes, has increased markedly over the past few years in many countries. Although early melanoma is curable through surgical excision, the prognosis of advanced melanoma is very poor, this tumor being resistant to current therapies. Thus there is a need for new therapies to improve the treatment of advanced melanoma. This review provides an overview of recent discoveries in the genetics of melanoma which could offer new therapeutic opportunities. |
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Keywords: | melanoma receptor tyrosine kinase MAPK pathway PI3K pathway cAMP pathway small molecule inhibitor |
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