| 斑蝥素对G1/S期肾小管上皮细胞ATP的调节 |
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| 引用本文： | 沈青,姚裕家,李如英,丁翠玲,侯立朝,孙绪德. 斑蝥素对G1/S期肾小管上皮细胞ATP的调节[J]. 南方医科大学学报, 2004, 24(10): 1192-1193,1196 |
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| 作者姓名： | 沈青 姚裕家 李如英 丁翠玲 侯立朝 孙绪德 |
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| 作者单位： | 第四军医大学西京医院儿科,陕西,西安,710032;四川大学华西二院儿科,四川,成都,610041;第四军医大学西京医院麻醉科,陕西,西安,710032 |
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| 摘 要： | 目的通过斑蝥素对G1/S期肾小管上皮细胞(RTECs)低氧损伤后细胞ATP代谢影响的研究,探讨斑蝥素稳定肌动蛋白微丝骨架系统的机制。方法将新生猪G1/S界面RTECs分为3组:实验组(氰化钠 斑蝥素)、缺氧组(氰化钠)和空白对照组,应用反相高效液相比较缺氧后各组细胞内ATP含量的变化。结果实验组细胞内ATP含量[(14.50±0.26)mmol/g蛋白]明显高于缺氧组[(4.25±0.11)mmol/g蛋白]和空白对照组[(8.58±0.13)mmol/g蛋白](P<0.01)。结论斑蝥素稳定肌动蛋白微丝骨架系统可能与抗RTECs低氧损伤后细胞能量代谢紊乱相关。
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| 关 键 词： | 肾小管上皮细胞 斑蝥素 三磷酸腺苷 肌动蛋白类 低氧 |
| 文章编号： | 1000-2588(2004)10-1192-02 |
| 修稿时间： | 2004-02-18 |
Cantharidin regulates intracellular ATP in G1/S-phase renal tubule epithelial cells |
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| SHEN Qing,YAO Yu-jia,LI Ru-ying,DING Cui-ling,HOU Li-chao,SUN Xu-deDepartments of Pediatrics and Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China. Cantharidin regulates intracellular ATP in G1/S-phase renal tubule epithelial cells[J]. Journal of Southern Medical University, 2004, 24(10): 1192-1193,1196 |
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| Authors: | SHEN Qing YAO Yu-jia LI Ru-ying DING Cui-ling HOU Li-chao SUN Xu-deDepartments of Pediatrics Anesthesiology Xijing Hospital Fourth Military Medical University Xi'an China |
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| Affiliation: | SHEN Qing1,YAO Yu-jia2,LI Ru-ying1,DING Cui-ling1,HOU Li-chao3,SUN Xu-de3Departments of Pediatrics1 and Anesthesiology3,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China, 2Department of Pediatrics,Second Hospital,West China School of Medical Science,Sichuan University,Chengdu 610041,China |
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| Abstract: | |
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| Keywords: | renal tubule epithelial cells cantharidin adenosine triphosphate actins hypoxia |
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