无功能胰岛细胞瘤9例报告

本文报告无功能胰岛细胞瘤9例,其中癌2例,分别于术后4个月和1年死亡,良性肿瘤7例,术后随诊3个月～18年均健在。患者均以上腹包块为主诉,随肿块逐渐增大可有上腹饱胀、疼痛、黄疸和消化道梗阻等相应的症状及体征。超声、胃肠透视、CT和腹腔动脉造影对定位诊断有较大帮助。行肿瘤切片免疫组织化学染色,其胰高血糖素、胰岛素及生长抑素均阴性,镜下区分良、恶性肿瘤的标志之一要视肿瘤有否转移。主要的治疗方法是手术切除肿瘤。

Non-functional Islet Cell Tumor.A Report of 9 Cases

This paper reports on 9 cases of non-functional islet cell tumor of the pancreas, 2 of which were carcinoma of the islet cell, one each died at 4 months and 1 year postoperatively. All the other 7 cases with benign tumors survived without tumor for 3 months to 18 years at follow-up. Upper abdominal palpable mass was the most frequent sign. Pain, jaundice and obstruction of alimentary canal may appear during the course of the growth of the tumor. Ultrasonography, X-ray examination of gastrointestinal tract, CT and selective arteriography were useful in localization of the tumor. With immunohistochemical methods, the pancreatic glucagon, insulin and somatostatin were negative in the tumor tissue. The main pathologic sign of distinguishing malignant from benign was metastases. Surgical resection seems to be the mainstay of treatment.