| 新生儿缺血缺氧性脑病免疫功能研究 |
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| 引用本文： | 王乃俊,刘平力. 新生儿缺血缺氧性脑病免疫功能研究[J]. 大理医学院学报, 2000, 9(2): 43-45 |
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| 作者姓名： | 王乃俊 刘平力 |
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| 作者单位： | 解放军六十医院成都军区儿科中心,大理 |
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| 摘 要： | 目的：检测３８例缺血缺氧性脑病患儿周血免疫球蛋白、Ｃ３、Ｔ淋巴细胞亚群，ＩＬ－２及ＳＩＬ－２Ｒ。方法：血清免疫球蛋白、补体Ｃ３、Ｔ淋巴细胞亚群ＳＩＬ－２Ｒ以及ＩＬ－２活性分别采用单向免疫扩散法，ＡＰＡＡＰ、ＭＴＴ比色法以及ＥＬＩＳＡ法。结果：与对照组比较，血清ＩｇＭ及补体Ｃ３、ＣＤ３、ＣＤ４以及ＣＤ４／ＣＤ８和ＩＬ－２明显降低（Ｐ〈０．０１）。而ＳＩＬ－２Ｒ值明显升高（Ｐ〈０．０１），ＣＤ６细胞无
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| 关 键 词： | 缺血缺氧性脑病 新生儿 免疫功能 |
Immune Function in Neonates with Hypoxic-ischemic Encephalopathy |
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| Wang Naijun Liu Pingli Zhang Kanhuai et al.. Immune Function in Neonates with Hypoxic-ischemic Encephalopathy[J]. Journal of Dali Medical College, 2000, 9(2): 43-45 |
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| Authors: | Wang Naijun Liu Pingli Zhang Kanhuai et al. |
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| Abstract: | Objective: To detect the serum immunoglobin (Ig), complement C3, T lymphocyte subsets, interleukin-2 (IL-2) and serum soluble IL-2 receptor (SIL-2R) of peripheral blood in 38 cases with hypoxic-ischemic encephalopathy. Method: Using single immunodiffusion test, MTT, APAAP and ELISA to detect the level of serum Ig, C3, SIL-2R, IL-2 and T lymphocyte subsets. Results: The serum level of IgM, complement C3, CD3 and CD4, together with CD4 / CD8 and IL-2, obviously decreased in the patients with hypoxic-ischemic encephalopathy (test group) in comparison with those in the control group (P < 0.01). The SIL-2R significantly increased in the test group (P < 0.01) while CD8 did not show a prominent change (P > 0.05). Conclusion: The immune function is impaired in the neonates with hypoxic-ischemic encephalopathy (HIF). |
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| Keywords: | Hypoxic-ischemic encephalopathy Neonates Immune function |
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