细胞因子基因多态性与结核病易感性研究进展

结核病是发展中国家常见的疾病,病死率高.全球有近三分之一的人口感染结核分枝杆菌,但仅有10%的感染个体最终发展为临床结核,说明宿主的基因因素在结核病的发病机制中起着极其重要的作用.细胞因子是结核病免疫的重要组成部分,其水平与结核病易感性、严重程度和临床表现都有联系,因此编码细胞因子的基因在结核病易感性中有重要的作用.现就细胞因子基因多态性与结核易感性的关系作一综述.

Advance on relationship between cytokine gene polymorphisms and tuberculosis susceptibility

Tuberculosis (TB) remains a primary cause of morbidity and mortality in developingcountries. One third of the world's population is infected by Mycobacterium tuberculosis(Mtb),only 10% ofinfected individuals develop into clinical TB, which indicates that an essential role is involved with hostgenetic factors in TB susceptibility. Cytokines are significant ingredients in TB immunity, which proves to actin the susceptibility, severity and clinical outcome of disease, since single nucleoticle polymorphism in severalcytokine genes should provide a pivotal contribution for understanding of the susceptibility to TB. The reviewsummarizes the relationship between cytokine gene polymorphisms and tuberculosis susceptibility.