Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes |
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| Authors: | Robert C Hsueh Adrienne M Hammill Jamie A Lee Jonathan W Uhr Richard H Scheuermann |
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| Affiliation: | (1) Laboratory of Molecular Pathology and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA;(2) Immunology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA;(3) Cell Regulation Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA;(4) Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX, USA |
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| Abstract: | Background Immature B lymphocytes and certain B cell lymphomas undergo apoptotic cell death following activation of the B cell antigen receptor (BCR) signal transduction pathway. Several biochemical changes occur in response to BCR engagement, including activation of the Syk tyrosine kinase. Although Syk activation appears to be necessary for some downstream biochemical and cellular responses, the signaling events that precede Syk activation remain ill defined. In addition, the requirements for complete activation of the Syk-dependent signaling step remain to be elucidated. |
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