| 头孢他啶阿维巴坦治疗颅内多重耐药革兰阴性菌感染的进展 |
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| 引用本文： | 潘晶晶,高峻,孟海阳,李莹,韩超.头孢他啶阿维巴坦治疗颅内多重耐药革兰阴性菌感染的进展[J].中国新药与临床杂志,2021(2):86-90. |
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| 作者姓名： | 潘晶晶 高峻 孟海阳 李莹 韩超 |
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| 作者单位： | 汝州市人民医院;郑州大学第一附属医院药学部 |
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| 基金项目： | 河南省高等学校重点科研项目(19A360033)。 |
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| 摘 要： | 随着细菌耐药问题日益突出,颅内多重耐药(MDR)革兰阴性菌感染成为临床的棘手问题.近年上市的头孢他啶阿维巴坦(CAZ-AVI)对MDR革兰阴性菌显示出良好的抗菌活性,本文介绍了临床上8例CAZ-AVI治疗MDR革兰阴性菌颅内感染病例,除1例治疗失败外,其余7例均显示有效.CAZ-AVI有望成为临床治疗颅内革兰阴性菌感染...
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| 关 键 词： | 头孢他啶 阿维巴坦 革兰阴性菌感染 抗药性 细菌 |
Progress of ceftazidime-avibactam in treatment of intracranial infection caused by multidrug resistant Gram-negative bacteria |
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| PAN Jing-jing,GAO Jun,MENG Hai-yang,LI Ying,HAN Chao.Progress of ceftazidime-avibactam in treatment of intracranial infection caused by multidrug resistant Gram-negative bacteria[J].Chinese Journal of New Drugs and Clinical Remedies,2021(2):86-90. |
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| Authors: | PAN Jing-jing GAO Jun MENG Hai-yang LI Ying HAN Chao |
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| Institution: | (Ruzhou People's Hospital,Ruzhou HE-NAN 467599,China;Department of Pharmacy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou HE-NAN 450052,China) |
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| Abstract: | With the growing trend of bacterial drug-resistance, intracranial infection caused by multidrug resistant(MDR) Gram-negative bacteria have become a difficult clinical problem. Ceftazidime-avibactam(CAZ-AVI), which has been marketed in recent years, shows good antibacterial activity against MDR Gram-negative bacteria. This paper presents 8 cases of intracranial infection caused by MDR Gram-negative bacteria which were treated by CAZ-AVI. Except one case failed, the other 7 cases were effective. CAZ-AVI is expected to become a new clinical option for the treatment of intracranial Gram-negative bacterial infections. |
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| Keywords: | ceftazidime avibactam Gram-negative bacterial infections drug resistance bacterial |
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