血糖波动与老年人糖尿病血管并发症的研究进展

对于早期2型糖尿病患者,强化降糖治疗可以降低糖尿病微血管和大血管慢性并发症的发生风险。但老年糖尿病患者多伴有重要脏器功能减退、多种疾病共存、用药复杂、血糖波动幅度大及易发低血糖等特点,而过大的血糖波动和严重的低血糖被认为与糖尿病血管并发症密切相关。因此新的治疗理念认为,对于病程较长的老年2型糖尿病患者,在控制血糖的基础上,应减少血糖波动和严重低血糖的发生,从而减少糖尿病慢性并发症的发生发展。

Research progress of blood glucose fluctuation and vascular complications in aged patients with diabetes mellitus

Intensive glucose control can reduce the risk of microvascular and macrovascular complications in the patients with early type 2 diabetes mellitus (T2DM). However, elderly patients are characterized by being accompanied with multiple organ dysfunctions, coexistence of various diseases, complexity of medications, large fluctuations in blood glucose, and frequent hypoglycemia. Both excessive glucose fluctuations and severe hypoglycemia are closely associated with vascular complications. So a new treatment concept for the aged T2DM patients is that, on the basis of blood glucose controlling, we should reduce blood glucose fluctuation and occurrence of severe hypoglycemia, and thus, will reduce the occurrence and the development of chronic complications of T2DM.