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目的研究上海地区不同职业家庭不同年龄组的儿童幽门螺杆菌(H.pylori)感染的流行病学情况,以探讨不同经济状况下,儿童感染H.pylori的年龄阶段以及家庭H.pylori人群的分布对儿童H.pylori感染的影响。方法1119名就读于上海地区市中心与郊区学校的学生,男性568名,女性551名,年龄7～l4岁。问卷调查每位学生的居住环境、常住人口、父母职业和受教育程度、家庭的经济收入,有无消化道症状及慢性胃炎、溃疡病史等,同时采用ELISA方法检测血中H.pyloriIgG抗体。结果无症状儿童中7岁年龄组的H.pylori感染率为30.91%,在7～12岁年龄阶段随着年龄的增加H.pylori感染率也逐渐上升,平均年递增3.28%;工人和农民家庭的儿童较小的年龄即有较高的H.pylori感染率;生活在父母感染H.pylori家庭中的儿童更容易感染H.pylori。结论经济水平较低的家庭中,儿童H.pylori感染率高,而且较小年龄即有感染;H.pylori感染有家庭聚集现象。

Relation of environment to the prevalence of Helicobacter pylori infection in children

Objective We determined the seroprevalence of Helicobacter pylori infection among healthy children in different familial environments in Shanghai,and assessed the role of parental infection status in the transmission of H.pylori.Methods 1119 healthy individuals (568 boys and 551girls,respectively) were selected from urban and rural schools in Shanghai.A commercial enzyme immunoassay test for IgG to H.pylori was used.Demographic,sociological and environmental data were collected by face-to-face interviews using a standard questionnaire.Results The incidence of infection was calculated to increase 3.28% annally in children between ages 7 to 12 years.Children were infected in earlier age whose parents were workers and peasants.The infection rate was higher in children whose parents were infected too.Conclusion The infection is more prevalent in younger children of families in lower socioeconomic conditions.Improvement of living conditions may be effective for prevention.