中重度卵巢过度刺激综合征90例临床分析

目的探讨辅助生殖技术中的卵巢过度刺激综合征(OHSS)的高危因素及临床监测与治疗。方法对四川省人民医院90例中、重度卵巢过度刺激综合征临床资料进行回顾性分析。结果 (1)OHSS发生的高危因素:年轻患者、多囊卵巢综合征、过多卵泡数目以及妊娠。(2)妊娠的OHSS患者与未妊娠患者的病程分别为(18.56±12.19)d及(8.28±3.21)d,临床治疗时间及病程明显延长;未妊娠与妊娠患者所使用清白蛋白量为(130.43±24.22)g及(257.39±64.35)g,妊娠患者症状重、清蛋白治疗用量大。(3)扩容及输注清蛋白是治疗OHSS的有效措施,严重患者穿刺引流胸腔积液和腹水可缓解症状。结论 OHSS是辅助生育技术控制性超排卵治疗引起的医源性并发症,应予以正确的防治。

Clinical analysis on 90 patients with moderate and severe ovarian hyperstimulation syndrome

Objective To investigate the high risk factors,clinical manifestation and treatment of ovarian hy- perstimulation syndrome （OHSS） in assisted reproductive techniques. Methods Clinical data of 90 in-hospital OHSS patients from 2000 to 2011 were analysed retrospectively. Results （1） The high risk factors of OHSS： young women,polycystic ovarian syndrome （PCOS） ,a large number of follicles and pregnancy. （2） Longer disease process, more severe symptoms and larger amount albumin used for treatment of OHSS were observed in pregnant patients compared with non-pregnant ones. The disease process of pregnant patients and non-pregnant patients were （18.56±12.19） and （8.28±3.21）days,respectively. The amount of albumin were （130.43±24.22）g and （257.39±64.35） g. （3）Increasing effective blood volume and human serum albumin through intravenous dripping were the successful treatment of OHSS. Paracentesis was necessary for patients with severe ascites and hydrothorax. Conclusion OHSS is a serious complication of controlled ovarian hyperstimulation,which deserves proper prevention and treatment.