血清降钙素原定量在血流感染诊断中的临床价值

目的探讨血清降钙素原定量在血流感染诊断中的临床价值。方法采取前瞻性研究方法,根据病例入选标准和血流感染的诊断标准,收集血流感染和非血流感染患者各30例,采用t检验比较血流感染组和非血流感染组患者间血清PCT水平差异是否存在统计学意义,应用ROC曲线分析方法评估血清PCT水平在血流感染诊断中的临床价值。结果血清PCT水平在血流感染组和非血流感染组患者间的差异有统计学意义(P<0.01),血清PCT诊断血流感染的ROC曲线下的面积为0.911(95%的置信区间:0.841～0.981),以1.92ng/mL作为诊断临界值时,血清PCT对血流感染最具诊断价值,诊断灵敏度、特异性、阳性预测值、阴性预测值分别为96.7%、73.3%、80.6%、96.8%。结论血清PCT水平可作为一个有价值的血流感染实验室诊断指标。

Diagnostic value of quantitative measurement of serum procalcitonin in bloodstream infection

Objective To investigate the diagnostic value of quantitative measurement of serum procalcitonin in bloodstream infection. Methods We adopted a prospective study. According to case-inclusion criteria and blood- stream infection diagnostic criteria, we collected 30 cases of bloodstream infection and non-bloodstream infection, re- spectively. T-test was used to compare the difference of serum PCT levels between bloodstream infection group and non-bloodstream infection group. ROC curve assay was used to assess the value of serum procalcitonin levels in diag- nosis of bloodstream infection. Results The difference of serum PCT levels between the bloodstream infection group and non-bloodstream infection group was obviously significant （P〈0.01）. The area under the ROC curve of PCT in diagnosis of bloodstream infection was 0. 911 （95 % confidence interval： 0. 841- 0. 941）. When we used 1.92 ng/ml as a cut-off value, the value of serum procalcitonin levels in diagnosis of bloodstream infection was the best. The diag- nostic sensitivity, specificity, positive predictive value, and negative predictive value were 96.7%, 73.3 %, 80.6 %, and 96.8%,respectively. Conclusion Serum procalcitonin level is a valuable laboratory diagnostic indicator of blood- stream infection.