XE-5000检测网织血小板在血液病中的临床应用

目的探讨XE-5000检测网织血小板在血液疾病中的应用。方法应用XE-5000全自动血细胞分析仪测定特发性血小板减少性紫癜(ITP)32例、再生障碍性贫血(AA)30例、急性淋巴细胞白血病(ALL)35例、急性单核细胞白血病(AML)35例、急性早幼粒细胞白血病(APL)35例、慢性粒细胞白血病(CGL)、骨髓增生异常综合征(MDS)各10例及健康体检者30例的网织血小板比值(IPF%)、绝对值(IPF)、血小板计数(PLT)、平均血小板体积(MPV)。结果 IPF%:ITP组、CGL组显著高于健康对照组,差异有统计学意义(P<0.05);其他各组与健康对照组比较差异无统计学意义(P>0.05)。PLT:CGL组显著高于健康对照组,差异有统计学意义(P<0.05);其他各组显著低于健康对照组,差异有统计学意义(P<0.05)。IPF:CGL组显著高于健康对照组,差异有统计学意义(P<0.05)。MPV:ITP组显著高于健康对照组,差异有统计学意义(P<0.05)。ITP组治疗后的MPV显著降低,IPF显著升高(P<0.05)。结论网织血小板可反映骨髓巨核系统生成血小板的情况,有利于血小板疾病的病因诊断,也是疗效判定的有效指标。

Clinical application of blood platelets by XE-5000 test nets woven in blood disease

Objective To explore the application of the XE-5000 test nets woven in blood platelet disease.Methods 32 cases with idiopathic thrombocytopenic purpura（ITP）,30 cases with aplastic anemia（AA）,35 cases with acute lymphocytic leukemia（ALL）,35 cases with acute mononuclear cell leukemia（AML）,35 cases with acute promyelocytic leukemia（APL）,10 cases with chronic myeloid leukemia（CGL）,10 cases with myelodysplastic syndromes（MDS） and 30 normal cases were tested about nets woven platelet absolute value,platelet count IPF（PLT）,average platelet volume MPV by XE-5000 automatic blood analyzer.Results IPF% of ITP group and CGL group were higher than normal group（P0.05）,the other groups and normal group had no significant difference（P0.05）.PLT of CGL group was significantly higher than normal group（P0.05）,these of other groups were significantly lower than normal group（P0.05）.IPF of CGL group was significantly higher than normal group（P0.05）.MPV of ITP group was significantly higher than normal group（P0.05）,after treatment,MPV of ITP group was significantly lower,IPF of ITP group was significantly rised（P0.05）.Conclusion Nets woven platelet can reflect the bone marrow giant nuclear system generates platelet situation,be helpful for platelet disease diagnosis,also is the effective index of outcome.