尿路感染大肠埃希菌临床分布及耐药性分析

目的了解尿路感染大肠埃希菌的耐药现状,为临床合理使用抗菌药物提供试验依据。方法对该院泌尿系感染者分离出348株病原菌进行鉴定和体外药物敏感试验,采用法国生物梅里埃公司ATB鉴定系统对菌株进行鉴定,采用纸片扩散法(K-B)进行抗菌药敏感性试验。结果医院尿路感染标本分离的大肠埃希菌对常用抗菌药物表现出不同程度的耐药性,大肠埃希菌对碳青霉烯类抗菌药物亚胺培南和美洛培南敏感率为100.0%;对氨苄西林、头孢唑林、头孢呋辛和哌拉西林耐药率较高;对氟喹诺酮类抗菌药物环丙沙星、左氧氟沙星耐药率也大于60.0%。结论大肠埃希菌耐药率呈逐年上升趋势;临床应该重视病原菌的培养和药物敏感试验,根据药敏结果合理应用抗菌药物。

Distribution and drug resistance of Escherichia coil causing urinary tract infections

Objective To approach antimicrobial resistance of E. coli causing urinary tract infections and pro- vide experimental evidence for clinically reasonable choice of antibiotics. Methods 348 pathogen strains in urinary in- fection isolated from inpatients and outpatients were cultured and identified by ATB and K-B method was performed for drug sensitivity test. Results The antimicrobial resistance of ECO varied from commonly used antibiotics. E. coli was sensitive to carbapenems such as imipenem and meropenem. The resistance rate to ampicillin, cefazolin, Cefu- roxime and piperacillin were the highest. Those of ciprofloxacin and levofloxacin were higher than 65. 0%. Conclusion E. coli is the most common pathogens of the urinary tract infection,whose resistance is raised. Clinician should pay attention to the changes in drug-resistance of E. coli and prescribe the antibiotic correctly.