质子泵抑制剂加铝碳酸镁 百乐眠治疗难治性胃食管反流病56例

目的探讨质子泵抑制剂(PPI)联合铝碳酸镁、百乐眠治疗难治性胃食管反流病(GERD)的疗效。方法采取随机对照临床试验。对照组58例以PPI加促动力药等治疗;治疗组56例在对照组的基础上联合铝碳酸镁咀嚼片1g,一日3次;百乐眠胶囊4片,一日2次,疗程2～4周。结果难治性GERD患者胃灼热、上腹疼痛较GERD组少,但恶心、睡眠障碍、吸烟、饮酒较多。总有效率治疗组91.1%,对照组74.2%(P<0.05),不良反应轻微。结论 PPI联合铝碳酸镁、百乐眠等治疗难治性GERD疗效较好,无明显不良反应。

Combination therapy of proton pump inhibitor, hydrotalcite and bailemian in 5 6 patients with refractory gastroesophageal reflux disease

Objective To observe the effect of proton pump inhibitor （PPI） combined with hydrotalcite and bailemian in treating refractory gastroesophageal reflux disease （GERD）. Methods Random clinical contrast test was used ill the practice. 58 patients in control group using the combination therapy of PPI and prokinetics drugs. 56 patients in treatment group combined with hydrotalcite lg for 3 times a day and 4 capsules of bailemian for two times a day in the basis of the treatment in control group. The treatment course ranges from 2 weeks to 4 weeks. Results This contrast demonstrated that the refractory GERD patients showed less heartburn and superior belly pain,but more nausea, sleep disorder, smoking, and drinking habit in GERD patients. The effective curative rate in treatment group was 91.1% and 74.2% （P〈0.05） in Control group, with very little adverse reation in both groups. Conclusion The combination therapy of PPI, hydrotalcite and bailemian in treating refractory GERD is effective, without obvious adverse reaction.