冠心病患者血尿酸水平与血小板参数的关系探讨

目的探讨冠心病(CHD)患者血尿酸(SUA)水平与血小板参数的关系。方法对77例CHD患者及51例体检健康者进行SUA与血小板参数[血小板计数(PLT)、大血小板比率(P-LCR)、平均血小板体积(MPV)及血小板体积分布宽度(PDW)]检测。根据SUA水平另将CHD患者分为CHD伴高尿酸血症(HUA)组和CHD正常尿酸组。并对各组检测结果进行统计学分析。结果 CHD患者与健康对照组比较,SUA、P-LCR、MPV、PDW显著增高(P<0.01、P<0.05),PLT显著减低(P<0.01)。CHD伴HUA组与CHD正常尿酸组比较,P-LCR、MPV、PDW显著增高(P<0.05),PLT显著减低(P<0.01)。CHD正常尿酸组与健康对照组比较,血小板参数差异均无统计学意义(P>0.05)。CHD患者SUA与P-LCR、MPV、PDW呈显著正相关(r=0.207、0.213、0.238,P<0.05),与PLT无显著相关性(P>0.05)。结论 CHD患者SUA水平与血小板参数关系密切,HUA可能通过促进血小板活化、增强血小板黏附、聚集和释放功能而参与CHD的发生发展。

Relationship between serum uric acid level and platelet parameters in patients with coronary heart disease

Objective To explore the changes and relationship between serum uric acid （SUA） level and plate- let parameters in patients with coronary heart disease （CHD）. Methods 77 CHD patients and 51 healthy subjects for physical examinations were collected. Platelet parameters （PLT,P-LCR, MPV and PDW） were measured with blood cell counter,and SUA level was measured with automatic biochemical analyzer. CHD patients were classified into CHD with normal SUA group and CHD with hyperuricemia （HUA） group by the level of SUA. The data in all groups were analyzed statistically. Results Compared with the healthy control group, SUA, P-LCR, MPV and PDW levels in CHD group were apparently higher （P〈0. 01,P〈0. 05） and PLT level was lower （P〈0.01）. Compared with CHD with normal SUA group,P-LCR,MPV and PDW levels in CHD with HUA group were apparently higher （P〈0.05） and PLT level was lower （P〈0.01 ）. Compared with the healthy control group, PLT, P-LCR, MPV and PDW levels in CHD with normal SUA group were not apparently different （P〉0.05）. Pearson correlation analysis showed that SUA level was significantly positively correlated with P-LCR, MPV and PDW levels in patients with CHD （r=0. 207,0. 213,0. 238,P〈0.05）. Conclusion SUA level and platelet parameters in patients with CHD are closely related. High level of SUA may result in CHD by increasing the activation,adhesion,aggregation and release function of platelet.