急性 CO 中毒后迟发性脑病的临床研究

目的：探讨急性ＣＯ中毒后迟发性脑病（ＤＥＡＣＭＰ）的发病机理、诊断和治疗方法。方法：对本病患者的多项免疫和生化指标进行检测，观察患者的脑电图（ＥＥＧ）、脑电地形图（ＢＥＡＭ）、诱发电位（ＶＰ）和脑ＣＴ改变及高压氧（ＨＰＯ）和紫外线照射充氧自血回输疗法（Ｕ ＢＩＯ）对本病的疗效。结果：本病患者的多项免疫和生化指标有不同程度改变，ＥＥＧ、ＢＥＡＭ、ＶＰ和ＣＴ检查有不同程度异常，两种疗法的近期显效率均明显高于对照组。结论：免疫功能紊乱、神经递质和自由基代谢异常在ＤＥＡＣＭＰ的发生和病理发展过程中起重要作用，ＥＥＧ、ＢＥＡＭ、ＶＰ和ＣＴ检查对诊断和预后判断均有一定价值，ＨＰＯ和ＵＢＩＯ治疗疗效显著。

Clinical Study on Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

Objective: To study on pathogenic mechanism,diagnosis and treatment of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).Methods: Immune and biochemical indexes in the patients were measured;EEG,BEAM,evoked potential (VP) and brain CT were examined; the curative effect of the hyperbaric oxygen (HPO) and ultraviolet blood irradiation and oxygenation (UBIO) on the patients were observed Results: There were abnormal with varied degree in immune and biochemical indexes,EEG,BEAM,VP and CT in the patients .The stort term marked rate in two treated groups were significantly higher than control.Conclusion: Dysfunction of immunity, dysbolism of neurohumors and free radical play a important roles in invasion and development of the disease; EEG,BEAM,VP and brain CT were valuable to diagnosis and prognostic identication;HPO and UBIO were effective to the disorder.