自身免疫性甲状腺炎89例临床病理分析

目的探讨自身免疫性甲状腺炎的临床病理学特点。方法回顾性分析89例自身免疫性甲状腺炎的临床表现，病理变化。结果女性84例，男性5例，年龄以21～50岁(73例)为好发年龄段，病程多为1～5年(47例)，甲状腺肿大同时伴甲状腺恶性肿瘤7例。组织学表现：甲状腺滤泡普遍萎缩，残留的滤泡增大嗜酸性变，大量淋巴细胞浸润并形成滤泡和大量纤维组织增生及玻璃样变。结论自身免疫性甲状腺炎是一种与自身免疫性反应有关的疾病，病变早期临床常难以明确诊断，细针穿刺活检对诊断有很大帮助。

Autoimmune thyroiditis:clinicopathological analyses of 89 cases

Objective To investigate the clinical and pathological characteristics of autoimmune thyroiditis. Methods The clinical and pathological changes of 89 cases of autoimmune thyroiditis were reviewed and analysed. Results In all cases there were 84 females and 5 males,with two peak incidence, decades of the third (29 cases) and fifth (33 cases).The course in most cases ranged from 1 to 5 years,and size increase subsequent with malignant neoplasm took place in 4 cases.Microscopically diffused follicles atrophy was seen,and plasma of the remanent follicle cells showed oncocytic changes.Lymphocytes infiltrated and germinal center formed.Hyperplasia of fibrous tissue followed by hyaline degeneration was also found. Conclusion Autoimmune thyroiditis is a disease related with autoimmune reaction.It is difficult to diagnose it in early stage,and fine needle aspiration is of great value.