Ursodeoxycholic Acid in Neonatal Hepatitis and Infantile Paucity of Intrahepatic Bile Ducts: Review of a Historical Cohort |
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Authors: | M A Kotb |
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Institution: | (1) Department of Pediatrics, Cairo University, 5, Street 63 El Mokatam, P.O. Box 85, El Mokatam, 11571 Cairo, Egypt |
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Abstract: | We retrospectively reviewed the role of ursodeoxycholic acid in infants having nonsurgical cholestasis attending the Hepatology
Clinic, New Children Hospital, Cairo University, Egypt, from 1985 until 2005. Files of 496 infants with neonatal hepatitis
and 97 with intrahepatic bile duct paucity were included; of them 241 (48.6%) and 52 (46.4%) received 20–40 mg/kg/day ursodeoxycholic
acid for 319.2 ± 506.9 days and 480.3 ± 583.3 days, respectively. The outcome of infants with neonatal hepatitis with intake
of ursodeoxycholic acid and those without was: 108 (44.8%) and 179 (70.2%) successful (P = 0.000), 11 (4.6%) and 13 (5.1%) improved (P = 0. 474), 112 (46.5%) and 61 (23.9%) suffered failed outcome (P = 0.000), and 10 (4.1%) and 2 (0.78%) died (P = 0.014), respectively. Likelihood of successful outcome with ursodeoxycholic acid intake was 0.345 (P = 0.000), and that of deterioration was 2.76 (P = 0.000). For those having intrahepatic bile duct paucity likelihood of successful outcome with ursodeoxycholic acid intake
was 0.418 (P = 0.040) and that of deterioration was 2.64 (P = 0.028). Ursodeoxycholic acid failed in management of this cohort of infants with nonsurgical cholestasis. |
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