Main roads to melanoma |
| |
Authors: | Giuseppe Palmieri Mariaelena Capone Libera Maria Ascierto Giusy Gentilcore David F Stroncek Milena Casula Maria Cristina Sini Marco Palla Nicola Mozzillo and Paolo A Ascierto |
| |
Institution: | (1) Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche (CNR), Sassari, Italy;(2) Istituto Nazionale Tumori "Fondazione Pascale", Napoli, Italy;(3) Cell Processing Section, Department of Transfusion Medicine Clinical Center, NIH, Bethesda, MD, USA |
| |
Abstract: | The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify
the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify
the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main
molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have
been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated.
Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates
the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal
melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of
various effectors acting on different molecular pathways. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|