| 阵发性房颤诱发大鼠心房肌电重构特征研究 |
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| 引用本文： | 汤依群,孙书娟,尹月淼,汪旻晖,黄潞,单娇娇.阵发性房颤诱发大鼠心房肌电重构特征研究[J].中国临床药理学与治疗学,2011,16(11):1205-1209. |
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| 作者姓名： | 汤依群 孙书娟 尹月淼 汪旻晖 黄潞 单娇娇 |
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| 作者单位： | 中国药科大学临床药学教研室,南京210009,江苏 |
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| 基金项目： | 国家新药创制重大专项，江苏省自然科学基金 |
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| 摘 要： | 目的:探讨氯化钙-乙酰胆碱混合液引起的房颤大鼠心房电重构特征。方法:雄性SD大鼠,随机分为正常组和模型组,每组20只。CaCl210mg/mL+ACh 66μg/mL混合液尾静脉注射诱发大鼠房颤,连续诱发7d,正常组静脉注射生理盐水7d。心电图监测大鼠房颤持续时间、心房复极相关心电图参数变化。7d后,观察正常和房颤大鼠心房肌有效不应期,Western-blot法测定心房肌通道蛋白Kv 1.5、Kv 4.2/4.3,钙稳蛋白FKBP 12.6和缝隙连接蛋白Cx40的表达。结果:Ach-CaCl2连续静脉注射引起大鼠房颤持续时间逐渐延长,与正常组相比,房颤大鼠P波变宽,Pd增大,心房有效不应期缩短(P<0.01),同时心房肌Kv 1.5、Kv 4.2/4.3表达下降,FKBP12.6减少,Cx40含量下降(P<0.05)。结论:氯化钙-乙酰胆碱混合液持续给予7d,大鼠心房发生电重构,特征符合或接近临床房颤基质电重构特征。
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| 关 键 词： | 心房颤动 电重构 缝隙连接蛋白40 |
Characteristics of atrial electrical remodeling in rats induced by paroxysmal atrial fibrillation |
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| TANG Yi-qun,SUN Shu-juan,YIN Yue-miao,WANG Min-hui,HUANG Lu,SHAN Jiao-jiao.Characteristics of atrial electrical remodeling in rats induced by paroxysmal atrial fibrillation[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(11):1205-1209. |
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| Authors: | TANG Yi-qun SUN Shu-juan YIN Yue-miao WANG Min-hui HUANG Lu SHAN Jiao-jiao |
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| Institution: | TANG Yi-qun,SUN Shu-juan,YIN Yue-miao,WANG Min-hui,HUANG Lu,SHAN Jiao-jiao Department of Clinical Pharmacy,China Pharmaceutical University,Nanjing 210009,Jiangsu,China |
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| Abstract: | AIM:To investigate the characterisics of atrial electrical remodeling induced by atrial fibrillation(AF) at molecular level.METHODS: Male SD rats were randomized into 2 equal groups.Rats of control group were administrated physiological saline(i.v.) for 7 days.The others were injected ACh-CaCl2(i.v.) for 7 days.AF duration and ECG parameters were measured.On day 8,all rats were anesthetized and the atriums were immediately excised for measuring AERP,the expression of Kv 1.5,Kv4.2/4.3,FKBP12.6 and Cx40 prote... |
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| Keywords: | Atrial fibrillation Electrical remodeling Connexin 40 |
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