|
|||||
|
|
| 维拉帕米增强氯胺酮对小鼠的镇痛作用 | |
| 引用本文： | 武玉清,周成华,张永.维拉帕米增强氯胺酮对小鼠的镇痛作用[J].中国临床药理学与治疗学,2011,16(11):1201-1204. |
| 作者姓名： | 武玉清 周成华 张永 |
| 作者单位： | 1. 徐州医学院麻醉药理学教研室,徐州221002,江苏 2. 徐州医学院药学院药理学教研室,徐州221002,江苏 3. 徐州市第六人民医院泌尿外科,徐州221002,江苏 |
| 基金项目： | 国家自然科学基金，江苏省高校自然科学基金重大项目，江苏省高等学校大学生实践创新训练计划项目，江苏省青蓝工程优秀青年骨干教师资助项目 |
| 摘 要： | 目的:观察钙通道拮抗剂维拉帕米对静脉麻醉药氯胺酮镇痛效应的影响。方法:取40只小鼠,雌雄各半,随机分为4组:生理盐水对照组(NS)、氯胺酮处理组(K)、维拉帕米处理组(V)、维拉帕米和氯胺酮联合用药组(V+K),通过醋酸致小鼠扭体法观察小鼠给药后扭体潜伏期和次数的变化。另取40只小鼠,雌雄各半,随机分为上述4组,利用甩尾实验分别观察给药后小鼠对热水和冰水痛阈值的改变。结果:维拉帕米单独用药对小鼠扭体潜伏期和次数、热水和冰水痛阈值均无显著影响;氯胺酮能够延长醋酸致小鼠扭体的潜伏期,并且减少醋酸致小鼠扭体的次数,升高小鼠对热水和冰水甩尾痛阈值;而维拉帕米能够进一步增强氯胺酮延长小鼠扭体潜伏期,减少扭体次数和升高小鼠甩尾痛阈值的效应。结论:维拉帕米能够显著增强氯胺酮对小鼠的镇痛效应。 |
| 关 键 词： | 维拉帕米 氯胺酮 镇痛作用 小鼠 |
Verapamil enhanced the analgesic effect of ketamine in mice |
|
| WU Yu-qing,ZHOU Cheng-hua,ZHANG Yong.Verapamil enhanced the analgesic effect of ketamine in mice[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(11):1201-1204. | |
| Authors: | WU Yu-qing ZHOU Cheng-hua ZHANG Yong |
| Institution: | WU Yu-qing1,ZHOU Cheng-hua2,ZHANG Yong3 1 Department of Anesthetic Pharmacology,Xuzhou Medical College,2 Department of Pharmacology,3 Department of Urinary Surgery,the Sixth People's Hospital of Xuzhou City,Xuzhou 221002,Jiangsu,China |
| Abstract: | AIM:To observe the analgesic effects of ketamine combind with verapamil in mice.METHODS: 40 mice were randomly divided into 4 groups: normal saline group(NS),ketamine group(K),verapamil group(V) and verapamil combind with ketamine group(V+K).The method of stretching induced by acetic acid was adopted.In another experiment,40 mice were randomly divided into 4 groups above.The pain thresholds of mice to hot and ice water were observed through tail-flick experiment.RESULTS:Ketamine prolonged stretching latent ... |
| Keywords: | Verapamil Ketamine Analgesic effect Mouse |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |