慢性肝炎、肝硬化与消化性溃疡的研究

为研究肝源性溃疡（ＨＰＵ） 的临床特征及其可能的发病机制，分析了１６４ 例慢性肝病患者及３６ 例急性肝炎患者的ＨＰＵ 发生情况，并观察了ＨＰＵ 患者血清微量元素变化。结果：①慢性肝病患者ＨＰＵ 发生率为４０ ％ ，其中十二指肠球溃疡占８８ ．８ ％ ；②平均发病年龄４６ ．８ 岁；临床症状不典型；③ＨＰＵ 发生率与肝脏病变程度有关；④ＨＰＵ 患者血清Ｚｎ 明显降低（ Ｐ＜ ０ ．０５） ，Ｆｅ 明显增加（ Ｐ＜ ０ ．０５） 。结果提示，ＨＰＵ 不同于普通消化性溃疡；其病因和发病机制不完全清楚，可能是与肝病有关的胃粘膜攻击因子增强及防御因子减弱等多因素共同作用的结果。

Peptic Ulcer in Patients with of Gastroenterology, Chronic Liver Diseases

To study clinical and endoscopic feature and possible pathogenesis of hepatogenous peptic ulcer( HPU) , The endoscopic and clinical materials were analysed and microelements of 164 patients with chronicliver diseases and 36 patients with acute hepatitis were detected by WFX 1Datomic absorption spectrophotometry . The incidence of HPU was 40 % . Of them , Duodenal ulcer accounted for 88 .8 % . Average age was 46 .8 year old .Atypicalsy mptomtic HPU was observed .Seru m Zn was decreased( P < 0 .05) and Fe wasslightly increased( P < 0 .05) . The positive relationship between theincidence of HPU and the degree ofliver diseases was observed . The resultshowed that HPUdiffered from com mon peptic ulcer,and the pathogenesisis unclear .It was may be results from increased attactfactors and decreased protect factors in patients with chronicliver diseases .