Hypothalamic pathology in Alzheimer's disease |
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| Authors: | C B Saper D C German |
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| Affiliation: | 1. Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, IL 60637 U.S.A.;2. Department of Neurology, University of Chicago, Chicago, IL 60637 U.S.A.;3. Department of Psychiatry, University of Texas Health Science Center, Dallas, TX 75235 U.S.A.;4. Department of Physiology, University of Texas Health Science Center, Dallas, TX 75235 U.S.A.;1. Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Krakow 30-688, Poland;2. Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland;3. Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Krakow 30-688, Poland;4. Department of Chemical Technology, Poznan University of Technology, Berdychowo 4, Poznan 60-965, Poland;5. Chair of Pharmacology, Jagiellonian University Medical College, Grzegorzecka 16, Krakow 31-531, Poland;1. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, The University of Houston, 1441 Moursund Street, Houston, TX 77030, USA;2. Hubei University of University affiliated Taihe Hospital, 30 South Renmin Road, Shiyan, Hubei, China;3. Medical College of Wisconsin Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA;1. Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir 35340, Turkey;2. Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey;3. Department of Neurology, Dokuz Eylül University Medical School, Balçova, Izmir 35340, Turkey;4. Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey |
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| Abstract: | The hypothalamus was examined in 3 cases of Alzheimer's disease and 3 control brains, using combined acetylcholinesterase (AChE) and thioflavin-S staining. Neurons undergoing neurofibrillary degeneration were restricted to 3 AChE-positive cell populations (lateral tuberal, lateral posterior and tuberomammillary) that have been found in the rat and monkey to project to the cerebral cortex. Our results suggest that the neurofibrillary degeneration in the hypothalamus involves primarily neurons that innervate cortical areas involved by Alzheimer's disease. This finding is consistent with the hypothesis that Alzheimer's disease is transmitted from neuron to neuron via normal neuronal connections. |
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