杏仁核和扣带回毁损对甲基苯丙胺大鼠边缘区多巴胺受体的影响

目的　探讨立体定向杏仁核和扣带回的联合毁损对甲基苯丙胺 (MAP)大鼠脑内边缘区多巴胺D2受体表达的影响。方法　 4 0只SD大鼠随机分为对照组、MAP组、MAP加毁损组和MAP加假毁损组 ,每组各 10只 ;采用经腹腔注射MAP制备精神分裂症MAP模型 ,立体定向 射频毁损杏仁核和扣带回 ,免疫组织化学ABC法观察边缘区D2受体的表达。结果　与对照组比较 ,MAP组及MAP加假毁损组大鼠边缘区D2受体表达有非常显著性差异(P <0 0 1) ;MAP加毁损组大鼠边缘区D2受体阳性细胞数目与对照组比较无显著性差异 (P <0 0 1)。结论　杏仁核和扣带回的联合毁损可以抑制使用MAP而诱发的边缘区D2表达的亢进。

The effect of nucleus amygdalae and cingulum bundle lesion on dopamine receptor 2 in the brim region in methamphetamine rats

Objective To explore the effect of nucleus amygdalae and cingulum bundle lesion using stereotacfic technique on dopamine receptor 2 in brim region in methamphetamine (MAP) rats. Methods 40 Sprague Dawley rats were randomly divided into four groups:control group,MAP group,MAP and leasion group and MAP and pseudo lesion group. The nucleus amygdalae and cingulum bundle were destructed by radio frequency (RF) using stereotactic technique. Immunohistochemical ABC method was used to experiment the dopamine receptor 2 in brim region in MAP rats. Results Compared with control group, there are much more electropositive cells in brim region in MAP group and MAP and pseudo lesion group. However, there are fewer electropositive cells in lesion group and control group. Conclusions Lesion of nucleus amygdalae and cingulum bundle could restrain the haughty expression of dopamine receptor 2 in brim region because methamphetamine employ in rats.