| 磷酸二酯酶3抑制剂的功能和临床应用 |
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| 引用本文： | 张博,尤启冬,高署. 磷酸二酯酶3抑制剂的功能和临床应用[J]. 安徽医药, 2010, 14(10): 1220-1221. DOI: 10.3969/j.issn.1009-6469.2010.10.055 |
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| 作者姓名： | 张博 尤启冬 高署 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏,南京,210009;合肥合源医药科技有限公司,安徽,合肥,230088 |
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| 摘 要： | 磷酸二酯酶3（PDE3）是cAMP的水解酶,参与人体许多生理活动的调节。磷酸二酯酶3抑制剂升高细胞内cAMP水平,具有强心、血管舒张、抗血小板凝聚、抗增殖等作用,在心力衰竭和间歇性跛行等症的治疗中具有临床价值。
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| 关 键 词： | 磷酸二酯酶 3 抑制剂 心力衰竭 间歇性跛行 |
Functions and therapeutic applications of type III phosphodiesterase (PDE3) inhibitor |
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| ZHANG Bo,YOU Qi-dong,GAO Shu. Functions and therapeutic applications of type III phosphodiesterase (PDE3) inhibitor[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(10): 1220-1221. DOI: 10.3969/j.issn.1009-6469.2010.10.055 |
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| Authors: | ZHANG Bo YOU Qi-dong GAO Shu |
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| Affiliation: | ZHANG Bo1,YOU Qi-dong1,GAO Shu2(1.Department of Pharmaceutical Chemistry,China Pharmaceutical University,Nanjing 210009,China,2.Hefei Cosource Medicine Technology Co.,LTD,Hefei 230088,China) |
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| Abstract: | Type III phosphodiesterase(PDE3) hydrolyzes cAMP,regulating many physiology.PDE3 inhibitors upgrade intracellular cAMP,having pharmacological functions,such as,inotropic actions,vasodilatory actions,antiplatelet actions and antiproliferative ac-tions.PDE3 inhibitors are useful in the clinical treatment of heart failure and peripheral vascular disease. |
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| Keywords: | type III phosphodiesterase inhibitor heart failure peripheral vascular disease |
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