| AZFc区部分缺失与男性不育的关系 |
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| 引用本文： | 万磊,蔡志明. AZFc区部分缺失与男性不育的关系[J]. 中华男科学杂志, 2009, 15(2): 165-169 |
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| 作者姓名： | 万磊 蔡志明 |
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| 作者单位： | 1. 汕头大学医学院临床学院,广东,汕头,515041;北京大学深圳医院男性生殖医学与遗传深圳市重点实验室,广东,深圳,518036
2. 北京大学深圳医院男性生殖医学与遗传深圳市重点实验室,广东,深圳,518036 |
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| 摘 要： | Y染色体长臂无精子症因子(AZF)的微缺失是导致男性不育的一个重要原因。在AZF微缺失中以AZFc区的全部缺失(b2/b4缺失)最为常见,近年来的研究发现AZFc区的缺失种类繁多,不仅有AZFc区的全部缺失,还存在AZFc区部分缺失(gr/gr缺失,b1/b3缺失,b2/b3缺失),并且部分缺失也可能与男性不育有关。本文旨在对AZFc区部分缺失的研究进展及与男性不育的关系做一综述。
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| 关 键 词： | 男性不育 生精障碍 染色体微缺失 AZFc区部分缺失 |
Partial Deletions in the AZFc Region of the Y Chromosome Are Associated with Male Infertility |
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| WAN Lei,CAI Zhi-ming. Partial Deletions in the AZFc Region of the Y Chromosome Are Associated with Male Infertility[J]. National journal of andrology, 2009, 15(2): 165-169 |
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| Authors: | WAN Lei CAI Zhi-ming |
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| Affiliation: | WAN Lei1,2,CAI Zhi-ming2 1.School of Clinical Medicine,Medical College of Shantou University,Shantou,Guangdong 515041,China,2.Key Laboratory of Male Reproductive Medicine , Genetics,Shenzhen Hospital of Peking University,Shenzhen,Guangdong 518036 |
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| Abstract: | Microdeletion of the azoospermia factor in the Yq of the Y chromosome is one of the important causes of male infertility.Complete deletion of the AZFc region(b2/b4 deletion)is the most common type of AZF deletion.Recent studies have shown a variety of deletions of the AZFc region,including partial deletions,such as gr/gr deletion,b1/b3 deletion and b2/b3 deletion,which may also be associated with male infertility. |
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| Keywords: | male infertility spermatogenic impairment Y chromosome microdeletion AZFc partial deletion |
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