| 神经生长因子在小鼠体办的动力学,组织分布和排泄实验 |
| |
| 引用本文： | 黄才国,魏善建,姜华,宋树硅,李惠源,吴元芳. 神经生长因子在小鼠体办的动力学,组织分布和排泄实验[J]. 第二军医大学学报, 2001, 22(1): 65-67 |
| |
| 作者姓名： | 黄才国 魏善建 姜华 宋树硅 李惠源 吴元芳 |
| |
| 作者单位： | 1. 第二军医大学基础医学部卫生毒理学教研室,
2. 上海原子能研究所 |
| |
| 摘 要： | 目的:研究神经生长因子(NGF)在小鼠体内的动力学,组织分布和排泄情况,方法:采用核素标记结合电泳法测定小鼠肌注125I-NGF后不同时间体兴高采烈及组织中NGF含量结果:肌注后血浆药-时曲线符合二室分布模型,消除半衰期(t1/28)为3.1h,分布半衰期(t1/2ka)为25min,AUC为72.4mg.kg-1.h1.甲状腺,血浆,颌下腺,颈 上神经节,肾上腺素和肾脏中药物浓度轻高.结论:NGF在体内分布广,组织内含量量,主要通过尿液排泄.
|
| 关 键 词： | 神经生长因子 药代动力学 |
| 文章编号： | 025-879X(2001)01-0065-03 |
| 修稿时间： | 2000-06-29 |
Study on the pharmacolinetics,tissue distridution and excretion of nerve growsth factof in mice |
| |
| HUANG Cai-guo,WEI Shan-Jian,JIANG Hua,SONG Shu-Kui,LI Hui-Yuan,WU Yuan-Fang. Study on the pharmacolinetics,tissue distridution and excretion of nerve growsth factof in mice[J]. Former Academic Journal of Second Military Medical University, 2001, 22(1): 65-67 |
| |
| Authors: | HUANG Cai-guo WEI Shan-Jian JIANG Hua SONG Shu-Kui LI Hui-Yuan WU Yuan-Fang |
| |
| Abstract: | Objective:To study the pharmacokinetics,thissue distribution and secretion of nerve growth factor(NGF)in mice.Methods:The conecntration of NGF in various body fluids and tissue were determined by isotope tracer combined SDSPAGE method.Results:The plasma concenmtration-time curve was in accordance with the two-compartment pharmacokinetic model.The elimation half-life(t1/2β)was 3.1.The half-life of distribution(t1/2ka)was 5min.Tpeak was 25 min.AUC was 72.4 mg·kg-1·h-1.The concentrations of NGF were high in thyroid,blood,submaxillary glands,superior cervical ganglion,adrenasl and kidneys.Conclusion:NGF has a wide distribution,high tissue concentrationa nd excrtet mainly through the urine. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
|
