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高效液相色谱法测定人血浆中阿立哌唑浓度
引用本文:刘伟忠,黄伟侨,黎曙霞,王广发,王华成.高效液相色谱法测定人血浆中阿立哌唑浓度[J].中国药房,2007,18(2):111-113.
作者姓名:刘伟忠  黄伟侨  黎曙霞  王广发  王华成
作者单位:1. 广州市精神病医院、国家药品临床研究基地,广州市,510370
2. 中山大学附属第一医院药学部,广州市,510080
摘    要:目的:建立以高效液相色谱法测定人血浆中阿立哌唑浓度的方法。方法:血浆样品经液-液提取后,采用高效液相色谱法检测。色谱柱为C18,流动相为0.03mol·L-1醋酸铵-乙腈(34:66),流速为0.8mL·min-1,柱温为40℃,检测波长为257nm,灵敏度为0.01 AUFS。结果:阿立哌唑检测浓度线性范围为5.0~600.0ng·mL-1(r=0.999 5),提取回收率均大于90%。结论:该方法灵敏、准确、快速,适用于人血浆中阿立哌唑浓度的检测。

关 键 词:阿立哌唑  药动学  高效液相色谱法
文章编号:1001-0408(2007)02-0111-03
收稿时间:2006-03-09
修稿时间:2006-06-08

Determination of Aripiprazole in Human Plasma by HPLC
LIU Weizhong,WANG Guangfa,WANG Huacheng,HUANG Weiqiao,LI Shuxia.Determination of Aripiprazole in Human Plasma by HPLC[J].China Pharmacy,2007,18(2):111-113.
Authors:LIU Weizhong  WANG Guangfa  WANG Huacheng  HUANG Weiqiao  LI Shuxia
Abstract:OBJECTIVE: To establish a HPLC method for the determination of aripiprazole in human plasma by HPLC. METHODS: The plasma sample was determined by HPLC after subjected to liquid- liquid extraction .The separation was carried out on C18 column with clolumn temperature at 40℃. The mobile phase consisted of 0.03mol·L-1 ammonium acetate-acetonitrile(34:66) with a flow rate of 0.8mL·min-1 and detective wavelength of 257nm.The sensitivity was 0.01 AUFS. RESULTS:The linear range of aripiprazole was 5.0~600.0ng·mL-1(r=0.999 5) .The recovery rate was above 90% .CONCLUSION:The method is sensitive,accurate and rapid,and suitable for the determination of aripiprazole in human plasma.
Keywords:Aripiprazole  Pharmacokinetics  HPLC
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