急性肺损伤与细胞因子相关性的研究进展

急性肺损伤和急性呼吸窘迫综合征是导致患者急性呼吸衰竭和早期死亡的重要原因。尽管急性肺损伤的发病机制尚未完全阐明,但由炎性细胞、细胞因子和炎性介质构成的调节网络的失控,导致肺内皮细胞、肺泡上皮细胞、中性粒细胞和单核巨噬细胞为主的靶细胞受损已被广泛认同。大量实验研究表明,细胞因子的互相激活和级联反应是急性肺损伤和急性呼吸窘迫综合征的重要发生机制之一。本文对细胞因子在急性肺损伤和急性呼吸窘迫综合征发病中的作用及其机制予以综述。

Advancement in Relation between Acute Lung Injury and Cytokines

Acute lung injury（ALl） and acute respiratory distress syndrome（ARDS） are a major cause of acute respiratory failure in critically ill patients. There is considerable experimental and clinical evidence that pro-and anti-inflammatory cytokines and chemokines play a major role in the pathogenesis of inflammatory induced lung injury from sepsis, pneumonia, aspiration, and shock. Further research is needed to establish the contribution of cytokines to both the pathogenesis and resolution of ALl and ARDS. This article reviewed the role of cytokines in ALI and ARDS.