HMGB1、MMP9在子宫内膜癌中的表达和临床意义

目的：：探讨高迁移率组蛋白1(HMGB1）和基质金属蛋白酶-9(MMP-9）mRNA在子宫内膜癌中的表达水平和临床意义。方法：应用RT-PCR法检测正常子宫、单纯性增生症、非典型增生症和子宫内膜癌子宫内膜组织HMGB1和MMP9 mRNA的表达水平。结果：子宫内膜癌组织HMGB1、MMP-9 mRNA的表达量明显高于正常子宫、单纯性增生症、非典型增生症子宫内膜组织(P＜0.05)；子宫内膜癌组织HMGB1、MMP-9 mRNA的表达均与FIGO分期、淋巴结转移和浸润深度有关(P＜0.05）。结论：HMGB1、MMP-9在子宫内膜癌的发生、发展和转移过程中可能起着重要作用。

EXPRESSION AND CLINICAL SIGNIFICANCE OF HMGB1 AND MMP-9 IN ENDOMETRIAL CARCINOMA

ABSTRACT]Objective:To investigate the expression and clinical signiifcance of high-mobility group box 1 protein (HMGB1) and matrix metalloproteinases-9 (MMP-9) mRNA in endometrial carcinoma. Methods:RT-PCR was used to detect the HMGB1 and MMP-9 mRNA expression level in normal endometrial tissue, endometrial hyperplasia, atypical endometrial hyperplasia and endometrial carcinoma. Results:The HMGB1 and MMP-9 mRNA expression level in endometrial carcinoma were obviously higher than normal endometrial tissue, endometrial hyperplasia and atypical endometrial hyperplasia (P<0.05). In endometrial carcinoma, the expression of HMGB1 and MMP-9 were all related to FIGO stage, lymph node metastasis and inifltration depth (P<0.05). Conclusions:HMGB1 and MMP-9 may play important role in genesis, development and metastasis of endometrial carcinoma.