| 三氧化二砷对卵巢癌细胞抑制作用及机制的研究 |
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| 引用本文： | 杨国宏,张际绯,金华,刘志新. 三氧化二砷对卵巢癌细胞抑制作用及机制的研究[J]. 牡丹江医学院学报, 2007, 28(3): 1-3 |
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| 作者姓名： | 杨国宏 张际绯 金华 刘志新 |
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| 作者单位： | 牡丹江医学院,黑龙江,牡丹江,157011;牡丹江医学院,黑龙江,牡丹江,157011;牡丹江医学院,黑龙江,牡丹江,157011;牡丹江医学院,黑龙江,牡丹江,157011 |
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| 基金项目： | 牡丹江医学院校科研和教改项目 |
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| 摘 要： | 目的：探讨三氧化二砷（As2O3）对卵巢癌细胞HO-8910体外生长的影响及其相关机制.方法：用倒置显微镜对细胞进行观察,用免疫细胞化学染色法检测p53基因表达.结果：（1）三氧化二砷作用浓度在0～12.0 μmol/L时,随着剂量的增加对卵巢癌细胞抑制作用增强.（2）卵巢癌细胞p53基因表达增强.结论：较高浓度三氧化二砷对卵巢癌细胞株HO-8910细胞有生长抑制作用并呈剂量-时间依赖效应 As2O3作用引起卵巢癌细胞HO-8910细胞凋亡的机制与p53基因表达增强有关.
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| 关 键 词： | 三氧化二砷 卵巢癌 凋亡 |
| 修稿时间： | 2006-06-23 |
EFFECTS OF ARSENIC TRIOXIDE ON THE PROLILERATION OF OVARIAN CANCER CELL AND MECHANISM |
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| Yang Guohong et al. EFFECTS OF ARSENIC TRIOXIDE ON THE PROLILERATION OF OVARIAN CANCER CELL AND MECHANISM[J]. Journal of Mudanjiang Medical College, 2007, 28(3): 1-3 |
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| Authors: | Yang Guohong et al |
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| Affiliation: | Mudanjiang medical college Heilongjiang Mudanjiang 157011 |
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| Abstract: | Objective：The study was to investigate the effects of arsenic trioxide on the proliferation of ovarian cancer cell line HO - 8910 in vitro and relative mechanism. Methods： Morphological changes of cells were observed. Immunocytochemical staining was used to examine the expression of p53 gene. Results： （ 1 ） In vitro, arsenic trioxide of 0 -12.0μmol/L showed significant cor -relation to the HO -8910 cellular proliferation , and the degree of the inhibition enhanced with the increasing dose. （2） Higher concentrations of arsenic trioxide up - regulated p53 gene expressions was intensive. Conclusion：Arsenic trioxide at high concentrations could obviously inhibit the proliferation of ovarian cancer cell line HO- 8910 in vitro, and there was an dose- response relationship; the apoptosis mechanism of ovarian cancer cell line HO - 8910 was related with up - regulating of p53 gene expression. |
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| Keywords: | arsenic trioxide ovarian cancer apoptosis |
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