| 抗凋亡Bcl－2蛋白在人骨髓造血组织中的定位与分布 |
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| 引用本文： | 陈协群,黄高昇 ,王文亮. 抗凋亡Bcl－2蛋白在人骨髓造血组织中的定位与分布[J]. 解剖学报, 1996, 0(2) |
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| 作者姓名： | 陈协群 黄高昇 王文亮 |
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| 作者单位： | 第四军医大学西京医院血液科，第四军医大学西京医院病理学教研室 |
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| 摘 要： | 通过双际记免疫组织化学技术，探讨了抗细胞凋亡的Ｂｃｌ－２蛋白在１２例反应性骨髓组织中的定位与分布。结果显示，ｂｃｌ－２特异性单克隆抗体与荆豆素ＵＥＡ－１标记的骨髓造血细胞彼此分离、互不重叠。提示人骨髓中Ｂｃｌ－２蛋白阳性造血细胞源自粒系或淋巴系，而不是红系或巨核系。
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| 关 键 词： | Bcl－2蛋白，骨髓，荆豆素－1，造血细胞，免疫组织化学，人 |
LOCALIZATION AND DISTRIBUTION OF ANTI-APOPTOSIS PROTEIN BCL-2 IN HEMATOPOIETIC TISSUES OF BONE MARROW |
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| Chen Xiequn,Huang Gaosheng,Wang Wenliang. LOCALIZATION AND DISTRIBUTION OF ANTI-APOPTOSIS PROTEIN BCL-2 IN HEMATOPOIETIC TISSUES OF BONE MARROW[J]. Acta Anatomica Sinica, 1996, 0(2) |
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| Authors: | Chen Xiequn Huang Gaosheng Wang Wenliang |
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| Abstract: | Immunohistochemical double-labelling technique was applied in the present work to investigate the localization and distribution of anti-apoptosis protein Bcl-2 in 12 cases of bone marrow with reactive hyperplasia.The results exhibited that the hematopoietic cells labelled bv lectin UEA-1 were completely isolated from those reacted with monoclonal antibodies against Bcl-2 protein. These data establish that in bone marrow hematopoietic cells which were intensely stained for Bcl-2 originate in myeloid or lymphoid linage rather than erythroid or megakaryocytic linage. |
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| Keywords: | Bcl-2 protein Bone marrow UEA-1 Hematopoietic cells Immunohistochemistry Human |
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