Benzylthiouracil induced ANCA-positive vasculitis: study of three cases and review of the literature |
| |
Authors: | Frigui M Kechaou M Haddouk S Masmoudi A Kaddour N Masmoudi H Turki H Bahloul Z |
| |
Affiliation: | aService de médecine interne, CHU Hédi Chaker, route Ain Km 0,5, 3029 Sfax, Tunisie;bLaboratoire d’immunologie, CHU Habib Bourguiba, 3029 Sfax, Tunisie;cService de dermatologie et de vénéréologie, CHU Hédi Chaker, 3029 Sfax, Tunisie |
| |
Abstract: | IntroductionVasculitis with antineutrophilic cytoplasmic antibodies (ANCA) have been reported in patients treated with anti-thyroid drugs, especially propylthiouracil. Benzylthiouracil, which exhibits similar structural likeness with propylthiouracil, has been recently observed to be associated with Anca-positive vasculitis.Cases reportWe present a study of three women with Grave's disease aged 21, 37 and 40 years, who were treated with benzylthiouracil. These patients developed vasculitis characterized by constitutional symptoms (two patients), joint pain (two patients), renal involvement (two patients), pulmonary hemorrhage (one patient) and multiple neuropathy (one patient). All patients presented p-ANCA with anti-MPO pattern. Discontinuation of benzylthiouracil and treatment with corticosteroids improved systemic involvement in all patients.ConclusionMuch like other anti-thyroid drugs, benzylthiouracil can be associated with ANCA-positive vasculitis. Because of the gravity of this complication, clinical monitoring is recommended in patients taking benzylthiouracil. If vasculitis develops, the anti-thyroid drug should be discontinued and corticosteroid treatment, with immunosuppressors in some cases, is initiated. |
| |
Keywords: | Mots clé s: Antithyroï diens de synthè se Benzylthiouracile Vascularite Anca |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|