肺动脉高压的5-羟色胺/5-羟色胺转运体机制研究进展

肺动脉高压是临床常见的以肺血管阻力进行性增加并伴有不可逆的血管构型重塑为特征的疾病.5-羟色胺作为一种血管活性物质,可以通过5-羟色胺转运体介导,诱导肺动脉平滑肌细胞增殖,促进肺中小动脉构型重塑.因此,揭示5-羟色胺及5-羟色胺转运体在肺动脉高压形成发展中的重要作用,探讨其成为抗肺动脉高压药物治疗新靶点的可能性具有重要意义.

Involvement of serotonin and serotonin transporter in development of pulmonary arterial hypertension

Pulmonary arterial hypertension is a common disease with sustained elevation in pulmonary artery pressure, and irreversible pulmonary artery remodeling.As a kind of vasoactive substance,serotonin(5-HT)promotes smooth muscle cell proliferation and configuration reconstitution in pulmonary artery by serotonin transporter(SERT).So, it is meaningful to investigate the roles of 5-HT and SERT in the development of pulmonary arterial hypertension, and discuss the possibility of 5-HT/SERT to be a novel therapeutic approach for pulmonary arterial hypertension.