| 鼠双微粒体2蛋白、P53在口腔白斑和鳞癌中的表达及其相关性的研究 |
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| 作者姓名： | Han BF Wu PF Pan J Li Y Li LJ |
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| 作者单位： | 口腔疾病研究国家重点实验室, 四川大学, 成都610041 |
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| 摘 要： | 目的 研究鼠双微粒体2(MDM2)和P53在口腔白斑及鳞癌中的表达及其相关性.方法采用免疫组织化学SP方法对15例正常口腔黏膜组织、24例口腔白斑(OLK)组织及41例口腔鳞癌组织中的MDM2蛋白和P53蛋白进行检测.结果 正常黏膜中未见MDM2和P53阳性表达,口腔白斑和口腔鳞癌组织中MDM2阳性率分别为58.3%和...
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| 关 键 词： | 鼠双微粒体2 P53蛋白 口腔白斑 口腔鳞状细胞癌 |
| 收稿时间： | 2011-02-25 |
| 修稿时间： | 2011-02-25 |
Expression and its relationship of murine double minute 2 and P53 protein in oral leukoplakia and squamous cell carcinoma |
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| Han BF,Wu PF,Pan J,Li Y,Li LJ.Expression and its relationship of murine double minute 2 and P53 protein in oral leukoplakia and squamous cell carcinoma[J].West China Journal of Stomatology,2011,29(1):79-82. |
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| Authors: | Han Bang-feng Wu Ping-fan Pan Jian Li Yi Li Long-jiang |
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| Institution: | State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective To study the expression and its relationship of murine double minute 2(MDM2),P53 protein in oral leukoplakia and squamous cell carcinoma.Methods Immunohistochemical assay was used to detect the expression of MDM2 and P53 proteins in 15 normal oral epithelium tissues,24 cases of oral leukoplakias and 41 cases of oral squamous cell carcinomas.Results There were no positive expression of MDM2 and P53 in normal mucosa.With significantly difference compared with the normal group(P<0.05),the positive ra... |
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| Keywords: | murine double minute 2 P53 protein oral leukoplakia oral squamous cell carcinoma |
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