晚期非小细胞肺癌神经内分泌表达的化疗效果和预后分析

目的探讨伴有神经内分泌化倾向的晚期非小细胞肺癌化疗近期疗效及远期生存率的特点。方法采用免疫酶标法（ELISA）测定NSE值，将病例分为A、B两组，对比两组的临床特征，化疗的近期疗效及远期生存率。结果A组的近期化疗有效率63．9％，疗效持续时间2．5个月，一年生存率25．0％；B组的近期化疗有效率42．6％，疗效持续时间4．6个月，一年生存率38．3％。结论伴有神经内分泌化倾向的晚期非小细胞肺癌对化疗相对较为敏感，但疗效持续时间短，易于复发转移，预后较差，测定晚期非小细胞肺癌的血清NSE水平，可以作为预测化疗有效率及判断预后的指标之一。

Clinical and prognostic significance of the neuroendcrine and differentiation in non-small cell lung cancer

Objective To study differentiation of neuroendocrine in non-small cell lung cancer (NSCLC) and its effect on the responsiveness to chemotherapy and the prognosis. Methods Serum NSE levels were measured in 83 patients with previously untreated NSCLC. These cases were divided into two groups (A and B). The therapeutic efficacy was evaluated after two periods of chemotherapy and survival rate was examined. Results The response rate of chemotherapy was higher in the group A (63.9%) than in the group B (42.6%). The one year survival rate in the group A (25.0%) was lower than that in the group B (38.3%). Conclusion The differentiation of neuroendocrine may be one of the factors effecting the chemotherapy and prognosis in advanced NSCLC.