25-Hydroxy vitamin D levels in premenopausal Turkish women with uterine leiomyoma |
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Authors: | Zeynep Aslı Oskovi Kaplan Yasemin Taşçi Hasan Onur Topçu Salim Erkaya |
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Affiliation: | Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey |
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Abstract: | We aimed to evaluate the relationship between serum 25-hydroxy vitamin D levels and the risk of uterine fibroids in premenopausal women in Turkish population in this prospective observational cross-sectional study. Sixty-eight women with at least one uterine leiomyoma ≥10?mm were compared with 56 healthy controls. Serum 25-(OH) vitamin D3 levels were measured by electrochemiluminescence immunoassay. The groups were similar in terms of age, BMI, gravidity and parity numbers. The mean level of 25-(OH) D3 were 7.28?±?4.94?ng/ml and 78% of patients (n?=?97) had severe vitamin D deficiency (?10?ng/mL). Vitamin D levels were significantly lower in the study group (6.54?±?4.66?ng/ml vs. 8.18?±?5.16?ng/ml, respectively; p?=?.009). Vitamin D levels were not correlated with size, volume, localization and number of leiomyomas. Traditional covered clothing style, low education level and being housewife were risk factors for Vitamin D deficiency. This is the first study that investigates the vitamin D levels in women with leiomyomas in Turkish population. Influence of vitamin D on uterine leiomyoma formation to may lead to new preventive strategies in the future. |
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Keywords: | Vitamin D deficiency premenopausal women uterine leiomyoma |
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