A positive association between interleukin-1 receptor antagonist and insulin resistance in postmenopausal women |
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| Authors: | Chii-Min Hwu Hung-Hsiang Liou Chung-Jen Lee Bang-Gee Hsu |
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| Affiliation: | 1. Department of Medicine, Section of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan;2. Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan;3. Department of Internal Medicine, Division of Nephrology, Hsin-Jen Hospital, New Taipei City, Taiwan;4. Department of Nursing, Tzu-Chi University of Science and Technology, Hualien, Taiwan;5. Department of Medicine, Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;6. Faculty of Medicine, School of Medicine, Tzu Chi University, Hualien, Taiwan |
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| Abstract: | Objective: The purpose of this study was to determine whether higher circulating interleukin-1 receptor antagonist (IL-1Ra), an anti-inflammatory cytokine, was associated with insulin resistance in postmenopausal women.Methods: We measured IL-1Ra concentrations in 160 naturally postmenopausal women without a history of diabetes mellitus. A Pearson coefficient was computed to assess the relationship between plasma IL-1Ra and homeostasis model assessment of insulin resistance (HOMA-IR). The association between HOMA-IR and IL-1Ra plasma level above the median was assessed by logistic regression. Linear regression was used to explore the determinants of IL-1Ra plasma levels.Results: A significant positive correlation existed between IL-1Ra and HOMA-IR (r?=?0.42, p?p?=?.007).Conclusions: Our results demonstrated a positive association between plasma IL-1Ra and insulin resistance in postmenopausal women. This analysis suggested that insulin resistance was an important determinant of circulating IL-1Ra for these women. |
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| Keywords: | Association insulin resistance interleukin 1 receptor antagonist protein postmenopause women |
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