Effects of dehydroepiandrosterone supplementation on mice with diminished ovarian reserve |
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| Authors: | Xiufeng Lin Jing Du Yan Du Riran Wu Xiaowu Fang Yuechan Liao |
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| Affiliation: | 1. Reproductive Medical Center, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China;2. Reproductive Medical Center, Boai Hospital of Zhongshan, Zhongshan, Guangdong Province, China;3. Reproductive Medical Center, Boai Hospital of Zhongshan, Zhongshan, Guangdong Province, China |
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| Abstract: | Dehydroepiandrosterone (DHEA) has been used to improve the pregnancy rate in women with diminished ovarian reserve(DOR) during in vitro fertilization. We aimed to validate the effects of DHEA and identify the possible mechanisms. We constructed a mice model with DOR and analyzed the hormone parameters and follicle counts. In vivo experiment, FSH and LH concentrations in the serum were significantly elevated in the DOR group. However, the FSH and LH concentrations were partially reversed in the DOR?+?DHEA group. The E2, AMH and INHB were down-regulated in the DOR group and reversed in the DOR?+?DHEA group. Our study supported evidences that DHEA might modulate the hormone receptors in the ovary and hormone secretions to the peripheral circulation to regulate the ovary reserve functions. |
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| Keywords: | Dehydroepiandrosterone diminished ovarian reserve follicle-stimulating hormone |
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