Reversed end-diastolic flow in first-trimester umbilical artery: an ominous new sign for fetal outcome |
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| Authors: | Borrell A Martinez J M Farre M T Azulay M Cararach V Fortuny A |
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| Affiliation: | Prenatal Diagnosis Unit, Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), University of Barcelona Medical School, Villaroel 170, Barcelona 08036, Catalonia, Spain. |
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| Abstract: | OBJECTIVE: The purpose of this study was to assess the fetal outcome of first-trimester pregnancies with reversed end-diastolic flow in the umbilical artery. STUDY DESIGN: Doppler studies in the umbilical artery were carried out in 2970 consecutive pregnancies scanned at 10 to 14 weeks. RESULTS: We observed 11 (0.4%) cases of reversed end-diastolic flow. Of these, an autosomal trisomy was shown in 7 and a congenital heart defect in 2 additional fetuses. Fetal demise was observed in 5 pregnancies, neonatal death was observed in 1, and termination of pregnancy was carried out in 4. Only 1 fetus survived. CONCLUSIONS: Reversed end-diastolic flow in first-trimester umbilical artery signals an ominous prognosis even with normal karyotype. |
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