| 白术对小鼠S180肉瘤的抑瘤作用及肿瘤凋亡相关基因bcl-2表达的影响 |
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| 引用本文： | 郑广娟. 白术对小鼠S180肉瘤的抑瘤作用及肿瘤凋亡相关基因bcl-2表达的影响[J]. 生物医学工程研究, 2003, 22(3): 48-50 |
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| 作者姓名： | 郑广娟 |
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| 作者单位： | 山东中医药大学,济南,250014 |
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| 基金项目： | 山东省中医管理局资助项目 |
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| 摘 要： | 探讨白术对小鼠S180 肉瘤的抑瘤作用及肿瘤凋亡相关基因bcl - 2表达的影响。用病理形态学及荧光免疫组织化学法 ,通过光镜进行形态学观察 ,共聚焦显微镜观察并计数表达bcl- 2基因的瘤细胞数。结果表明 :白术各剂量组对小鼠S180肉瘤组织具有抑制作用 ,细胞形态学观察显示 ,白术可促进肿瘤细胞的凋亡及坏死 ,并引发相应的炎细胞反应。而且 ,白术各剂量组能明显降低小鼠S180 肉瘤凋亡相关基因bcl- 2的表达。白术可能通过调控肿瘤细胞凋亡抑制基因bcl - 2的表达而实现抑瘤作用。
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| 关 键 词： | 白术 S180肉瘤 bcl-2基因 |
| 文章编号： | 1672-6278(2003)03-0048-03 |
| 修稿时间： | 2003-06-25 |
Baizhu''''s Effect of Suppressing Tumors on S180 sarcoma and the Effect of Baizhu on Metastasis-associated Gene bcl-2 |
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| Zheng Guangjuan. Baizhu''''s Effect of Suppressing Tumors on S180 sarcoma and the Effect of Baizhu on Metastasis-associated Gene bcl-2[J]. Journal Of Blomedical Englneerlng Research, 2003, 22(3): 48-50 |
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| Authors: | Zheng Guangjuan |
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| Abstract: | To study Baizhu's effect of suppressing tumors on S 180 sarcoma and the effect of Baizhu on metastasis-associated gene bcl-2,we observed the tumor cell form with the method of fluorescent immunohistochemistry, and measured the gene expression of bcl-2 through confocal microscopy. The results indicated that the effect of the treated groups were better than that of the control group. They show that Baizhu can significantly resist the expression of metastasis-associated gene bcl-2 in S 180 sarcoma. Baizhu may suppress tumors through resisting the expression of metastasis-associated gene bcl-2. |
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| Keywords: | Baizhu S 180 sarcoma bcl-2 gene |
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