Substantially reduced expression of PIAS1 is associated with colon cancer development |
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| Authors: | Domenico Coppola Vevek Parikh David Boulware George Blanck |
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| Affiliation: | (1) Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA;(2) Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA;(3) Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd. MDC7, Tampa, FL 33612, USA;(4) Present address: Department of Pediatrics, College of Medicine, University of South Florida, Tampa, FL, USA |
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| Abstract: | Purpose Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-γ) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS’s also regulate STAT family members not directly involved in IFN-γ signaling. This project was designed to assess PIAS1 expression in colon cancer. Methods To determine whether PIAS1, one of the PIAS family members, or IFN-γ signaling pathway components could be used to stratify colon tumors, we stained tissue microarrays for PIAS1, interferon regulatory factor-1 (IRF-1) and STAT1α. Results PIAS1 staining of the colon cancer tissue microarrays indicated a strong correlation of normal colon cells, and adenomas, with high expression of both PIAS1 and IRF-1. Conclusion The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer. |
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| Keywords: | Interferon-gamma Colon cancer PIAS1 IRF-1 STAT1α Adenoma Tissue microarray |
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