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The somnolence syndrome in leukemic children following reduced daily dose fractions of cranial radiation |
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| Authors: | P Littman J Rosenstock G Gale R E Krisch A Meadows H Sather P Coccia B DeCamargo |
| Affiliation: | 1. Department of Radiation Therapy, University of Pennsylvania School of Medicine, USA;2. Cardinal Glennon Hospital for Children, USA;3. Department of Pediatrics, Children''s Hospital of Philadelphia, USA;4. Children''s Cancer Study Group, USA;5. Division of Pediatric Hematology Oncology, Rainbow Babies & Childrens Hospital, USA;6. Servico de Pediatria, Hospital A.C. Camargo, USA |
| Abstract: | A group of children with acute lymphocytic leukemia was studied to investigate if a reduction in daily dose fraction of cranial radiation would reduce the incidence of somnolence syndrome. Thirty-one evaluable patients received 100 rad X 18 cranial radiation therapy. Sixty-six similar evaluable patients were given 180 rad X 10. Both groups received the same chemotherapy including intrathecal methotrexate. Clinically detectable somnolence appeared in 58% of ech group without significant differences in the overall frequency or severity of somnolence (p greater than 0.5). This study failed to substantiate a radiation dose fraction size dependence for somnolence syndrome in children with acute lymphocytic leukemia. |
| Keywords: | Acute lymphocytic leukemia Somnolence syndrome Central nervous system leukemia |
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