Plasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus |
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| Authors: | Aylin Babalik Ismail Hakki Ulus Nadi Bakirci Tulin Kuyucu Huseyin Arpag Lale Dagyildizi Esen Capaner |
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| Affiliation: | Sureyyapasa Chest Disease and Thoracic Surgery Training and Research Hospital, Istanbul, Turkeya;Department of Pharmacology, Acibadem University School of Medicine, Istanbul, Turkeyb;Department of Public Health, Acibadem University School of Medicine, Istanbul, Turkeyc;Kaan Med Toxicology Laboratory, Istanbul, Turkeyd |
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| Abstract: | Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49% or 100% (P < 0.01), 66% or 100% (P < 0.05), 30% or 50% (P = 0.198), and 32% or 21% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients. |
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