Spontaneous Wheel Running Exercise Induces Brain Recovery via Neurotrophin-3
Expression Following Experimental Traumatic Brain Injury in Rats |
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| Authors: | Hyun Mo Koo Sun Min Lee Min Hee Kim |
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| Affiliation: | 1) Department of Physical Therapy, College of Science, Kyungsung University;2) Department of Occupational Therapy, Dongju University;3) Department of Physical Therapy, College of Health Science, Eulji University |
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| Abstract: | [Purpose] The aim of the present study was to investigate the expression ofneurotrophin-3 (NT-3) after applying spontaneous wheel running exercises (SWR) afterexperimental traumatic brain injury (TBI). [Subjects and Methods] Thirty maleSprague-Dawley rats were divided into 3 groups; 20 rats were subjected to controlledcortical impact for TBI, and then, animals were randomly collected from the SWR group andsubjected to wheel running exercise for 3 weeks. Ten rats were not subjected to any injuryor running exercise to compare with the effect of TBI and SWR. Immunohistochemistry,Western blotting, skilled ladder rung walking test, and 2,3,5-triphenyltetrazoliumchloride staining analysis for the evaluation of NT-3 expression were used to assess braindamage and recovery. [Results] The TBI-induced decrease in NT-3 expression was recoveredby wheel running exercise. Moreover, decreased ischemic volume and progressiveneurobehavioral outcome were observed in the SWR group. [Conclusion] Spontaneous runningexercise promotes brain recovery and motor function through an increase in expression ofNT-3.Key words: Neurotrophin-3, Traumatic brain injury, Wheel running exercise |
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